Seminar Series

Heparin sulphate (HS); a novel therapeutic in CNS repair?

I will show data that supports the concept that HS and modifications of their structures may be a useful target for CNS repair. The talk will cover a description of the problems for designing strategies for CNS repair with a focus on the astrocyte which becomes reactive and inhibits repair after CNS damage. Data will be shown how heparin and modifications on it sulphation levels can have important consequences on the astrocyte and its repair potential. Modified heparins will also be used in complex myelinating cultures and result presented to show how they can affect neurite outgrowth myelination and astrocytosis. Some in vivo data will also be shown Related Papers Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface. O'Neill P, Lindsay SL, Pantiru A, Guimond SE, Fagoe N, Verhaagen J, Turnbull JE, Riddell JS, Barnett SC. Glia. 2016 Aug 18. doi: 10.1002/glia.23047 Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation. Higginson JR, Thompson SM, Santos-Silva A, Guimond SE, Turnbull JE, Barnett SC. J Neurosci. 2012 Nov 7;32(45):15902-12. doi: 10.1523/JNEUROSCI.6340-11.2012.