Seminar Series

The impact of obesity on stroke: evidence from preclinical studies

Obesity leads to an increased risk of many complications such as diabetes, liver disease, certain forms of cancer, osteoarthritis, hypertension and cardiovascular disease. What is less widely appreciated and studied is the effect obesity on the brain. Obesity is a risk factor for stroke although there is conflicting data as to whether obesity leads to poorer prognosis. However, after experimental ischaemic stroke obesity leads to worse outcome including enhanced disruption of the blood-brain barrier. This talk will cover the experimental studies of stroke in obese rodents and discuss the role of endothelial vesicles in blood-brain barrier permeability. The effect of obesity on blood flow and long-term recovery will also be discussed.