Seminar Series

Novel neuronal targeting and blocking molecules based on clostridial neurotoxins

We are investigating mechanisms of clostridial neurotoxins' action in neurons, targeting technologies for neuronal drug delivery and applications of non-paralysing botulinum constructs for long-lasting pain alleviation. Tetanus and botulinum neurotoxins are exquisitely-designed molecular machines which carry several useful functions to be exploited in biology and medicine. Currently, botulinum neurotoxins type A is being used widely to block muscle activity. We propose that re-engineering of potent botulinum toxins can widen biomedical applications and also shed light on neuronal function in health and disease.