Novel neuronal targeting and blocking molecules based on clostridial neurotoxins
We are investigating mechanisms of clostridial neurotoxins' action in neurons, targeting technologies for neuronal drug delivery and applications of non-paralysing botulinum constructs for long-lasting pain alleviation. Tetanus and botulinum neurotoxins are exquisitely-designed molecular machines which carry several useful functions to be exploited in biology and medicine. Currently, botulinum neurotoxins type A is being used widely to block muscle activity. We propose that re-engineering of potent botulinum toxins can widen biomedical applications and also shed light on neuronal function in health and disease.