Novel MRI Methods for Assessing Cerebrovascular Disease
Magnetic resonance imaging has a rich history of providing non-invasive anatomical and pathological information in the human body. More recently, MRI has also been used to provide quantitative functional and metabolic information. In the case of cerebrovascular disease, MRI can report on upstream causative pathology (for example the presence and composition of atherosclerotic plaque), as well as the downstream consequences of any vascular pathology (for example the formation of any collateral flow pathways, or the presence of tissue perfusion deficit, metabolic stress or, worse, infarct). In this presentation a number of newly developed methods for studying cerebrovascular disease will be presented, including the use of a novel black blood preparation module for vessel wall imaging; the use of arterial spin labeling for both vessel-selective vessel visualization and for tissue perfusion mapping; and the use of chemical exchange saturation transfer imaging for the detection of pH changes in tissue. Some early results showing lumen imaging and vessel wall imaging of the intracranial vessels at 7 Tesla will also be shown.