Seminar Series

Selective neuronal loss and inflammation in the rescued ischaemic penumbra

Professor Jean-Claude Baron is an eminent stroke Neurologist, previously the first chair of Stroke Medicine at the University of Cambridge and currently Research Director at the University of Paris. Professor Baron has applied advanced brain imaging, particularly PET, to the study of acute stroke, demonstrating and defining the characteristics of the ischaemic penumbra in human stroke in the early 1990s. Subsequent work included investigated of hypoxic and neuroinflammatory markers using PET, and correlation of acute perfusion changes with both clinical evolution of stroke and subsequent focal cell loss, applying rigorous analyses of MRI, PET and CT perfusion imaging to identify the pathophysiological mechanisms.