Cortical centers or white matter networks for human spatial orienting?
Homologous neural networks seem to exist in the human left and right hemispheres tightly linking cortical regions straddling the sylvian fissure. It is argued that these perisylvian networks serve different cognitive functions, a representation for language and praxis in the left hemisphere and a representation for processes involved in spatial orienting in the right. The tight perisylvian anatomical connectivity between superior/middle temporal, inferior parietal and ventrolateral frontal cortices might explain why lesions at these distant cortical sites around the sylvian fissure in the human right hemisphere can lead to the same disturbance of orienting behavior, namely to spatial neglect. Beyond, the lecture will address the most recent strategies in imaging-based lesion studies and their applications to clinical questions.