Seminar Series

Towards an Objective Evaluation of EEG/MEG Source Estimation Methods

The question “What is the spatial resolution of EEG/MEG?” can only be answered with many ifs and buts, as the answer depends on a large number of parameters. I will describe a framework for resolution analysis of EEG/MEG source estimation, focusing primarily on linear methods. The spatial resolution of linear methods can be evaluated using the resolution matrix, which contains the point-spread and cross-talk functions (PSFs and CTFs), respectively. Both of them have to be taken into account for a full characterization of spatial resolution. They can be used to compute a range of quantitative resolution metrics, which should cover at the last three aspects of those functions: localization accuracy, spatial extent, and relative amplitude. We applied these concepts to evaluate the benefit of combining EEG and MEG measurements, and to compare weighted and normalized L2-minimum-norm estimation and beamformers. We confirmed and extended previous results, showing that adding EEG to MEG improves spatial resolution, and that different methods offer different compromises among different resolution criteria. We hope that our approach will help EEG/MEG researchers in the interpretation of source estimation results, the design of new experiments, and the development of new MEG systems.